中文名 | 菝葜 |
英文名 | SMILAGENIN |
别名 | 菝葜 菝葜配基 菝葜配質 异菝葜皂甙 异知母皂苷元 化合物 T4954L |
英文别名 | SMILAGENIN (25r)-spirostan-3β-ol (25R)-SPIROSTAN-3BETA-OL 25R,5BETA-SPIROSTAN-3BETA-OL 5BETA,20ALPHA,22ALPHA,25D-SPIRANOSTAN-3BETA-OL 5-BETA, 20-ALPHA, 22-ALPHA, 25D-SPIROSTAN-3-BETA-OL |
CAS | 126-18-1 |
EINECS | 204-775-8 |
化学式 | C27H44O3 |
分子量 | 416.64 |
密度 | 1.0362 (rough estimate) |
熔点 | ~185°C |
沸点 | 474.91°C (rough estimate) |
比旋光度 | D25 -69° (c = 0.5 in chloroform) |
折射率 | 1.4700 (estimate) |
酸度系数 | 15.14±0.70(Predicted) |
体外研究 | Smilagenin (10 μM; 24 hours) increases SH-SY5Y cell survival compared with Aβ(25-35) intoxicated cells. Smilagenin (10 μM; 24 hours) increases neurotrophic factor (GDNF) and neurotrophic factor (BDNF) mRNA level by promoting CREB phosphorylation in 1-methyl-4-phenylpyridimium (MPP + ) treated SH-SY5Y cells. Cell Viability Assay Cell Line: SH-SY5Y cells Concentration: 10 μM Incubation Time: 24 hours Result: Elevated the SH-SY5Y cell viability. RT-PCR Cell Line: SH-SY5Y cells Concentration: 10 μM Incubation Time: 24 hours Result: Increased GDNF and BDNF transcription. |
体内研究 | Smilagenin (intragastric administration; 10 or 26 mg/kg, once daily; 60 days) prevents the impairment of dopaminergic neurons in chronic MPTP/probenecid-induced mouse model. Animal Model: MPTP/probenecid-induced mouse model Dosage: 10 or 26 mg/kg Administration: Intragastric administration; 10 or 26 mg/kg; once daily; 60 days Result: Ameliorated locomotor ability of MPTP/probenecid-lesioned mice. |
WGK Germany | 3 |
FLUKA BRAND F CODES | 10 |
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